PDE5 is an enzyme that can reduce the levels of cGMP in the body. cGMP is a molecule that helps relax the smooth muscles and dilate blood vessels, which increases blood flow to the penis, facilitating an erection. PDE5 inhibitors are a well-established and effective treatment for erectile dysfunction and are also used for pulmonary arterial hypertension. They can significantly improve sexual function in men with ED, allowing for more spontaneity in sexual activity. However, they should only be used under the guidance of a healthcare provider, particularly since they can interact with other medications and health conditions.
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